MiR‐21 Contributes to Cytokine‐Induced Beta Cell Dysfunction via Inhibition of mRNAs Regulating Beta Cell Identity
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منابع مشابه
Balsamic Vinegar Improves High Fat-Induced Beta Cell Dysfunction via Beta Cell ABCA1
BACKGROUND The aim of this study was to investigate the effects of balsamic vinegar on β-cell dysfunction. METHODS In this study, 28-week-old Otsuka Long-Evans Tokushima Fatty (OLETF) rats were fed a normal chow diet or a high-fat diet (HFD) and were provided with tap water or dilute balsamic vinegar for 4 weeks. Oral glucose tolerance tests and histopathological analyses were performed there...
متن کاملE2F8 contributes to human hepatocellular carcinoma via regulating cell proliferation.
The E2F family member of transcription factors includes the atypical member E2F8, which has been little studied in cancer. We report that E2F8 is strongly upregulated in human hepatocellular carcinoma (HCC), where it was evidenced to contribute to oncogenesis and progression. Ectopic overexpression of E2F8 promoted cell proliferation, colony formation, and tumorigenicity, whereas E2F8 knockdown...
متن کاملResponse: Balsamic Vinegar Improves High Fat-Induced Beta Cell Dysfunction via Beta Cell ABCA1 (Diabetes Metab J 2012;36:275-9)
Corresponding author: Bong Soo Cha Department of Internal Medicine, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-752, Korea E-mail: [email protected] We sincerely appreciate the interest and comments regarding our study, “Balsamic Vinegar Improves High Fat-Induced Beta Cell Dysfunction via Beta Cell ABCA1,” which was published in Diabetes & Metabolism Journal 2012;36...
متن کاملLetter: Balsamic Vinegar Improves High Fat-Induced Beta Cell Dysfunction via Beta Cell ABCA1 (Diabetes Metab J 2012;36:275-9)
Corresponding author: Jae-Hyoung Cho Department of Endocrinology and Metabolism, Seoul St. Mary’s Hospital, The Catholic University of Korea School of Medicine, 222 Banpo-daero, Seocho-gu, Seoul 137-701, Korea E-mail: [email protected] It is well known that lipotoxicity can cause β-cells injury and/ or dysfunction as well as glucotoxicity [1-4]. If we could expect improvement of β-cell dy...
متن کاملBeta Cell Dysfunction and Insulin Resistance
Beta cell dysfunction and insulin resistance are inherently complex with their interrelation for triggering the pathogenesis of diabetes also somewhat undefined. Both pathogenic states induce hyperglycemia and therefore increase insulin demand. Beta cell dysfunction results from inadequate glucose sensing to stimulate insulin secretion therefore elevated glucose concentrations prevail. Persiste...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2019
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.2019.33.1_supplement.694.13